The primary neuronal cells are more resistant than PC12 cells to α-synuclein toxic aggregates

ConclusionBy putting these data together, it is clear that PHN is more resistant than PC12 toward αSN cytotoxicity even in the presence of rising cytoplasmic ROS and Ca2+ levels. Exploring the supporting mechanisms which PHN uses to be more resistant to αSN cytotoxicity can help to open a roadmap toward therapeutic plans in PD and other synucleinopathy disorders.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research