Molecules, Vol. 24, Pages 600: Preparation and Evaluation of Novel Transfersomes Combined with the Natural Antioxidant Resveratrol

Molecules, Vol. 24, Pages 600: Preparation and Evaluation of Novel Transfersomes Combined with the Natural Antioxidant Resveratrol Molecules doi: 10.3390/molecules24030600 Authors: Pey-Shiuan Wu Yu-Syuan Li Yi-Ching Kuo Suh-Jen Jane Tsai Chih-Chien Lin Resveratrol (tran-3,5,4′-trihydroxystibene, RSV) is a kind of polyphenol which has anti-inflammatory, antioxidant, anti-allergy, and anti-cancer properties, as well as being a scavenger of free radicals and preventing cardiovascular diseases. However, it is quite unstable in light, heat, and other conditions, and decays easily due to environmental factors. For these reasons, this study used a new type of carrier, transfersome, to encapsulate RSV. Transfersome consists of phosphatidyl choline (PC) from a liposomal system and non-ionic edge activators (EA). EA are an important ingredient in the formulation of transfersome; they can enhance the flexibility of the lipid bimolecular membrane of transfersome. Due to its ultradeformability, it also allows drugs to penetrate the skin, even through the stratum corneum. We hope that this new encapsulation technique will improve the stability and enhance the permeability of RSV. Concluding all the tested parameters, the best production condition was 5% PC/EA (3:1) and 5% ethanol in distilled water, with an ultrasonic bath and stirring at 500 rpm, followed by high pressure homogenization. The optimal particle size was 40.13 ± 0.51 nm and the ent...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research