Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro

In this study, we show that pretreatment with acetyl salicylic acid (ASA) enhanced the c ytotoxic antitumor effect of NO in vitro. Combination of low doses of JS-K and ASA revealed a dose-dependent synergistic increase of necrotic cell death under circumvention of classical apoptosis and alteration of the metabolic calcium level. These findings provide an opportunity to improve currentl y used therapeutic strategies in the treatment of gliomas with a well-established remedy.
Source: Molecular Neurobiology - Category: Neurology Source Type: research