Intestinal dysmotility in a zebrafish ( Danio rerio ) shank3a;shank3b mutant model of autism

ConclusionsOur data and rescue experiments support mutations inSHANK3 as causal for GI transit and motility abnormalities. Reductions in serotonin-positive EECs and serotonin-filled ENS boutons suggest an endocrine/neural component to this dysmotility. This is the first study to date demonstrating DT dysmotility in a zebrafish single gene mutant model of ASD.

http://link.springer.com/10.1186/s13229-018-0250-4

Source: Molecular Autism - January 31, 2019 Category: Molecular Biology Source Type: research