Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate

Conclusions/interpretationWe are currently evaluating the safety and efficacy of intraocular islet transplantation in a phase 1 clinical trial. In this study, we demonstrate immunosuppression-free long-term survival of intraocular islet allografts in mice and in a baboon using transient peri-transplant immune intervention. These results highlight the potential for inducing islet transplant immune tolerance through the intraocular route. Therefore, the current findings are conceptually significant and may impact markedly on clinical islet transplantation in the treatment of diabetes.

Source: Diabetologia - January 31, 2019 Category: Endocrinology Source Type: research