Tumour MLH1 promoter region methylation testing is an effective prescreen for Lynch Syndrome (HNPCC)

Conclusions
Quantitative MLH1 promoter region methylation using pyrosequencing is superior to BRAF codon 600 mutation status in identifying constitutional mutations in mismatch repair deficient tumours.

Source: Journal of Medical Genetics - November 17, 2014 Category: Genetics & Stem Cells Authors: Newton, K., Jorgensen, N. M., Wallace, A. J., Buchanan, D. D., Lalloo, F., McMahon, R. F. T., Hill, J., Evans, D. G. Tags: Colon cancer, Screening (oncology), Epidemiology Cancer genetics Source Type: research