PI3K γ (Phosphoinositide 3-Kinase γ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling.

Conclusions- PI3Kγ controls phenotypic modulation of VSMCs by regulating transcription factor CREB activation and YAP expression. Modulating PI3Kγ signaling on local vascular wall may represent a new therapeutic approach to treat proliferative vascular disease. PMID: 30651001 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30651001?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 17, 2019 Category: Cardiology Authors: Yu Q, Li W, Jin R, Yu S, Xie D, Zheng X, Zhong W, Cheng X, Hu S, Li M, Zheng Q, Li G, Song Z Tags: Arterioscler Thromb Vasc Biol Source Type: research