Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure
Demyelination, axonal loss and failure of tissue repair characterize MS lesions. Bone morphogenetic proteins (BMPs) signaling is associated with remyelination failure. Coco is one of the BMP antagonists. We found reduced Coco serum levels in relapsing-remitting MS (RR-MS) and primary progressive MS (PP-MS) patients compared to matched healthy controls (HC) and patients with rheumatoid arthritis. Exposure of P19 cells, in the presence of retinoic acid, BMP-2, or BMP-4 to Coco, at average sera level of MS patients failed to induce neuronal phenotype, in contrast to the average sera level of HC.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Karin Mausner-Fainberg, Moran Penn, Maya Golan, Moshe Benhamou, Smadar Gertel, Arnon Karni Tags: Short Communication Source Type: research
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