Target animal safety testing of an oral salicylanilide suspension, oxyclozanide, for the treatment of fascioliasis in bovine in China

Publication date: Available online 8 January 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Zhen Dong, Jichao Sun, Yubin Bai, Weiwei Wang, Yueming Zhu, Bing Li, Fusheng Cheng, Xiaojuan Wei, Enliang Song, Haijian Cheng, Fugui Jiang, Xuzheng Zhou, Jiyu ZhangAbstractThe aim of this study was to determine the potential toxicity risk of an oxyclozanide suspension to the target animal, bovine. In this experiment, 32 Simmental beef cattles were fattened and fed a full-price diet without antimicrobial agents. The test cattle were divided into 4 groups, which were treated with 0, 1, 3, and 5 times the recommended dosage through continuous intermittent oral administration at intervals of 2 days. The body weight of the cattle was recorded before and after the experiment, and the weight changes were calculated. The safety of the drugs was evaluated by weight gain, observation of clinical toxicity, haematology, clinical chemistry and histopathology. The results showed that the cows had different degrees of diarrhoea, loss of appetite and depression after administration. The results of clinicopathology had no significant effect. The results of pathological examination showed that there was a certain degree of damage in the 5 times recommended dose group. The recommended dose was safe to use. Thus, the recommended dose should be given by a single oral administration to ensure the safe use of this drug in the clinic.
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research