The Art of Transplantation: Conditioning Intensity for Allogeneic Hematopoietic Stem Cell Transplant

The search for the optimal conditioning regimen prior to allogeneic hematopoietic stem cell transplant (HCT) for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) has been ongoing for decades.[1, 2] Early conditioning regimens consisted of high-dose chemotherapy and radiation, now characterized as myeloablative conditioning (MAC), to achieve the aspired outcome of eliminating malignant disease with concomitant restoration of normal hematopoiesis. With experience and improved understanding of the graft-versus-leukemia effect, investigators began to lower the intensity of conditioning regimens.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research