Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology.

Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology. Biol Chem. 2018 Dec 01;: Authors: Gardiol D, Marziali F, Dizanzo MP, Cavatorta AL Abstract Human Disc large (DLG1) is a scaffolding protein that through the interaction with diverse cell partners participates in the control of key cellular processes such as polarity, proliferation and migration. Experimental data have mainly identified DLG1 as a tumor suppressor. An outstanding point for DLG1 protein is that altered DLG1 expression and DLG1 gene mutations were observed in different pathologies, including cancer and neurological and immunological disorders. Evident changes in DLG1 abundance and/or cell localization were identified in a number of studies suggesting its participation in molecular mechanisms responsible for the development of such illnesses. In this review, we focus on some of the latest findings regarding DLG1 alterations in different diseases as well as its potential use as a biomarker for pathological progression. We further address the current knowledge on the molecular mechanisms regulating DLG1 expression and the posttranslational modifications that may affect DLG1 cell localization and functions. Despite the advances in this field, there are still open questions about the precise molecular link between alterations in DLG1 expression and the development of each specific pathology. The complete...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research