Multiple Myeloma Therapy in Tawam Hospital. First Report from United Arab Emirates (UAE)

Conclusion:This is the first report on the management of MM patients in UAE. With a median follow-up of 216 days (range 3 to 839 days) the response rate to induction therapy was 72% (CR+ VGPR). We are unable to report progression free survival due to short follow-up. This response rate of 72% (VGPR or better) is less than the reported in the literature. This may partly be due to lack of patient data regarding induction therapy elsewhere, the use of double over triplet regimens and the absence of autoSCT facilities. Outcome measurement is a difficult task due to tendency of local citizens to travel outside UAE for treatment and the transient nature of the large expatriate population (88% of the total population of approximately 5.4 million)We are working on developing an infrastructure for consistent testing (CD138-selected FISH, consistent staging, use of PET-CT and bone marrow MRI as well as developing auto SCT facilities). We have formulated a uniform treatment plan based on weekly RVd based therapy for 16 weeks as induction followed by recommendation for Auto SCT. If auto SCT is not possible then patients will continue RVd therapy for a total of 12 cycles followed by maintenance lenalidomide till progression. The standardization of diagnosis, therapeutic approach and follow-up should optimize the care and outcomes of UAE MM patients.DisclosuresMcCarthy: Bristol Myers Squibb: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Research Funding; Karyopharm: Consultancy,...
Source: Blood - Category: Hematology Authors: Tags: 653. Myeloma: Therapy, excluding Transplantation Source Type: research

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This study was aimed at detecting NRAS G12D and NRAS G13C mutant genes among apparently healthy and haematologic malignant individuals, and to explore their association with some clinical and demographic factors as well as disease status and progression. A total of 200 cfDNAs, 100 each from haematologic malignant patients and blood donors, respectively, were analyzed for the presence of NRAS gene mutations in codons 12 and 13. These mutations were tested using multiplex allele-specific PCR (AS-PCR). The mutations were detected by selective amplification using mutation-specific synthetic oligonucleotides. NRAS G12D and NRAS...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
Publication date: January 2020Source: LWT, Volume 117Author(s): H. Staroszczyk, B. Kusznierewicz, E. Malinowska-Pańczyk, I. Sinkiewicz, K. Gottfried, I. KołodziejskaAbstractThe aim of the work was to study the feasibility of using aqueous extracts from rowanberry, blue-berried honeysuckle, and chokeberry pomace for the formulation of fish gelatin films with antioxidant and antimicrobial activity as well as improved mechanical and water barrier properties. The predominant phenolic components in rowanberry and chokeberry extracts were hydroxycinnamates, and in blue-berried honeysuckle extract anthocyanins. Although the gel...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 20 September 2019Source: Preventive Veterinary MedicineAuthor(s): A.S. Boerlage, H. Stryhn, B. Armstrong, K.L. HammellAbstractBacterial Kidney Disease (BKD) is an economically significant disease in salmonid aquaculture and commonly requires antibiotic treatments to reduce its impact. Once a pen of fish is diagnosed with BKD, fish are considered chronically infected, potentially until harvest. Although there appears to be little or no evidence to support it, it is often assumed that subclinical infections affect productivity over the long term. We used a 2-stage hierarchical interrupted t...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
CONCLUSION: The etiological diagnosis of hereditary urinary lithiasis in our study was made with considerable delay. Cystinuria was the most frequent etiology and primary hyperoxaluria was the most serious affection. LEVEL OF EVIDENCE: 4. PMID: 31537493 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Publication date: Available online 20 September 2019Source: Fish &Shellfish ImmunologyAuthor(s): Mohit Kumar Ram, B.T. Naveen Kumar, Sathish Rama Poojary, P.B. Abhiman, Prakash Patil, K.S. Ramesh, K.M. ShankarAbstractThe present study evaluated the biofilm (BF) of Vibrio anguillarum for oral vaccination of Asian seabass, Lates calcarifer. An 80-day experiment was carried out in circular fiber-reinforced plastic (FRP) tanks using free cell (FC) and BF of Vibrio anguillarum with triplicate in each. Heat-inactivated FC and BF cells at 107, 1010 and 1013 CFU/g fish/d were fed to fish for 20 days, agglutination antibody t...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 20 September 2019Source: Carbohydrate PolymersAuthor(s): Xiaoyue Xu, Liping Sun, Li Zhou, Yanju Cheng, Feng CaoAbstractChitosan oligosaccharide-valylvaline-stearic acid (CSO-VV-SA) nanomicelles were designed for topical ocular drug delivery, based on peptide transporter-1 (PepT-1) active targeting. Hydrogenated castor oil-40/octoxynol-40 (HCO-40/OC-40) mixed nanomicelles were also prepared according to Cequa, just approved by FDA. Both nanomicelles produced no significant cytotoxicity and difference in human corneal epithelial cells (HCEpiC) and human conjunctival epithelial cells (HConEp...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: 21 September 2019Source: New Scientist, Volume 243, Issue 3248Author(s): Donna Lu
Source: New Scientist - Category: Science Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): R. De Groote, E. De Bleser, S. Chintzoglou, P. Sooriakumaran, S. Nathan
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): V. Dassi, A. Kumar, S.Y. Qadri
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
BACKGROUND: Snake envenomation is associated with serious complications including infections, bleeding and, in rare occasions, thrombosis. Previous work by our group examined the association of snakebite and acute myocardial infarction. In this systematic ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news
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