Clinical Features and Predictive Factors of Early Mortality in Patients with MM Outside of Clinical Trials

ConclusionOne-fifth of the patients with NDMM died within two years due to myeloma progression, infection, and comorbidities. Our results suggested that high-risk CA and high levels of LDH did not have predictive value for EM in patients with NDMM outside of clinical trials. The presence of high CCI scores, low IADL scores, and decreases in iFLC (>65%) on day 7 from the baseline were independent prognostic factors, which could reflect both patient and disease factors. The combination of the CCI score, IADL score, ISS stage, and early reduction in iFLC may help in the identification of EM.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Kobayashi, H., Abe, Y., Miura, D., Narita, K., Kitadate, A., Takeuchi, M., Matsue, K. Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy Source Type: research