Pathogenesis Study of Down Syndrome Prone to Leukemia Using iPSCs from Trisomy 21 Patients

ConclusionWe established the cellular models of DS patients and derived differentiation into different cell types in vitro, which has the similar function with patient HSCs. On the basis of that, we found has_circ_0082802 may play important role in erythroid differentiation. We can further search for the potential drug targets thateffective against leukemia of DS patients. This approach would provide a powerful cell resource for clinical research and a useful model for the study of the mechanisms of DS-AMLDisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Jin, H., Wu, Z., Sun, H., Li, J. Tags: 501. Hematopoietic Stem and Progenitor Biology Source Type: research