Pathogenesis Study of Down Syndrome Prone to Leukemia Using iPSCs from Trisomy 21 Patients

ConclusionWe established the cellular models of DS patients and derived differentiation into different cell types in vitro, which has the similar function with patient HSCs. On the basis of that, we found has_circ_0082802 may play important role in erythroid differentiation. We can further search for the potential drug targets thateffective against leukemia of DS patients. This approach would provide a powerful cell resource for clinical research and a useful model for the study of the mechanisms of DS-AMLDisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 501. Hematopoietic Stem and Progenitor Biology Source Type: research

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Children with Down syndrome are known to have intellectual disability and a wide variety of malformations, such as congenital heart defects, small ears, small mouths, and other physical findings, along with medical conditions such as hypothyroidism, hip dislocation, hearing loss, cataracts, atlantoaxial instability, and leukemia. In 2011, the American Academy of Pediatrics (AAP) updated its guidelines for health supervision of the child with Down syndrome to assist the pediatrician to care for the child with Down syndrome (
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
CONCLUSION: Intellectually disabled persons can be treated in a multimodal, multiprofessional approach. As of early 2019, there were 38 medical centers for adults with intellectual disability or severe multiple disabilities in Germany (Medizinische Behandlungszentren für Erwachsene mit geistiger Behinderung oder schweren Mehrfachbehinderungen, MZEB), where they can be cared for with due attention to their special needs. PMID: 31888794 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis. Int J Mol Med. 2019 Jun;43(6):2303-2318 Authors: Salvi A, Vezzoli M, Busatto S, Paolini L, Faranda T, Abeni E, Caracausi M, Antonaros F, Piovesan A, Locatelli C, Cocchi G, Alvisi G, De Petro G, Ricotta D, Bergese P, Radeghieri A Abstract Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Specific microR...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Abstract Down's syndrome (DS; also known as trisomy 21; T21) is caused by a triplication of all or part of human chromosome 21 (chr21). DS is the most common genetic cause of intellectual disability attributable to a naturally-occurring imbalance in gene dosage. DS incurs huge medical, healthcare, and socioeconomic costs, and there are as yet no effective treatments for this incapacitating human neurogenetic disorder. There is a remarkably wide variability in the 'phenotypic spectrum' associated with DS; the progression of symptoms and the age of DS onset fluctuate, and there is further variability in the biophysi...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
Conclusions: This study identified potential relationships between maternal residential proximity to agricultural use of neurotoxic pesticides and poorer neurodevelopment in children. Received: 08 January 2016 Revised: 13 May 2016 Accepted: 14 June 2016 Published: 25 May 2017 Address correspondence to R. Gunier, Center for Environmental Research and Childrens Health (CERCH), School of Public Health, University of California at Berkeley, 1995 University Ave., Suite 265, Berkeley, CA 94704. Telephone: (510) 847-3858. E-mail: A.B. is a volunteer member of the Board for...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Review of Therapeutics Source Type: research
Conclusion Results from this study indicate that the MTRR C524T and A66G polymorphisms influence the risk of the occurrence of CHD in DS patients of Indian Origin. This is the first report from India highlighting the potential association of MTRR C524T and A66G polymorphisms with CHD in DS. We are also the first one to report two novel polymorphisms, T19775C and 19778_19778delG in DS with CHD group. Hence these four polymorphisms can be used to evaluate the risk of CHD in DS patients.
Source: Egyptian Journal of Medical Human Genetics - Category: Genetics & Stem Cells Source Type: research
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Source: Congenital Anomalies - Category: Genetics & Stem Cells Authors: Tags: Mini Review Source Type: research
ConclusionsA sizable proportion of children with newly diagnosed ALL have pre‐morbid DV that could potentially make them more vulnerable to reduced educational opportunities during treatment and neurotoxic late effects following treatment. Identification of the subset of children with ALL and DV is essential to direct early interventions and to study their long‐term outcomes. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Ras superfamily members act as molecular switches to many key signaling pathways, including proliferation cytoskeletal integrity, differentiation and cellular cargo transport. The Ras subfamily, consisting of KRas, NRas and HRas are the most widely studied Ras-family members due to the high instance of Ras activating mutation in human cancers. Rab subfamily members are important regulators of endocytosis, consisting of Rab5 (early endosome), Rab7 (recycling endosome) and Rab11 (late endosome). We have discovered that common binding partners exist between these Ras subfamilies, resulting in distinct interactions and regulat...
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Role of WT RAS and RAS Isoforms: Poster Presentations - Proffered Abstracts Source Type: research
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