Initial Therapy of Polycythemia Vera (PV) with Interferon Alfa (rIFNa) Compared to Hydroxyurea (HU) or Phlebotomy Only (PHL-O) Is Associated with a Lower Risk of Secondary Myelofibrosis

Conclusion. No significant difference in overall survival was observed between PV patients treated with initial rIFNa compared to initial HU or PHL-O. Initial treatment with rIFNa was associated with a lower risk of myelofibrotic progression. However, this risk was not statistically significant after adjusting for age at diagnosis, which was a predictor of myelofibrosis progression in this sample cohort. Finally, the risk-adjusted incidence of cardiovascular events was lower during IFNa therapy than HU therapy. A larger cohort is needed to validate these findings and accordingly, the data collection and analysis for our total cohort of 320 patients is ongoing.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 634. Myeloproliferative Syndromes: Clinical: Poster III Source Type: research