DNA damage in patients who underwent minimally invasive surgery under inhalation or intravenous anesthesia

In conclusion, general anesthesia with inhaled ISF and SVF or iv PF did not induce DNA strand breaks or alkali-labile sites in peripheral lymphocytes. Therefore, our results show that the genotoxic risk of these anesthetics, for healthy patients undergoing minimally invasive otorhinological surgery, is low or even absent. Highlights ► We investigated the genotoxic effects of two inhaled and one intravenous anesthetic. ► We evaluated healthy patients who underwent minimally invasive surgery. ► Comet assay was analyzed before, during and on the day following surgical procedure. ► No significant increase in DNA damage was detected within or among the three groups. ► Genotoxic risk of anesthesia for patients undergoing surgery is low or absent.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research