Sirtuin 5 promotes ischemia/reperfusion-induced blood-brain barrier damage after stroke

Circulating inflammatory cells influence endothelial function, which is important for vascular homeostasis and diseases [1]. Endothelial dysfunction is induced by several cardiovascular risk factors (e.g. hypertension, diabetes, and dyslipidemia) and environmental factors (e.g. hypoxia, infection, smoking, and air pollution) [2]. Recently, we have demonstrated that endothelial AMP-activated protein kinase (AMPK) plays an important role in the regulation of microvascular tone and blood pressure in mice [3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research