Vaginal Ureaplasma species increase chorioamnionitis in very preterm infants with preterm premature rupture of the membranes at & lt; 28  weeks of gestation

AbstractOur aim was to investigate the association between vaginalUreaplasma species (spp.) and the subsequent occurrence of chorioamnionitis (CAM), perinatal death, neonatal morbidity, and long-term neurodevelopmental impairments (NDIs) at 3  years of age. We analyzed 55 pregnant women with singleton pregnancy who had preterm premature rupture of the membranes (pPROM) at<  28+0 weeks of gestation, and delivered between 22+0 and 31+6 weeks at our tertiary hospital in 2007 –2016. NDIs were defined as either cerebral palsy or developmental delay evaluated at 1.5 and/or 3 years old. The presence ofUreaplasma spp.and Mycoplasma hominis were evaluated using urea-arginine broth and Mycoplasma PPLO Agar. The presence ofUreaplasma spp. in the vagina was positive in 41%. VaginalUreaplasma spp. was a significant risk factor for CAM; however, it was not significantly associated with the occurrence of perinatal death, pulmonary hypoplasia, respiratory distress syndrome, transient tachypnea of the newborn, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia defined as oxygen required and occasional ventilatory assistance required at week 36 as modified (BPD36), or NDIs. The crude odds ratio (95% confidence interval) ofUreaplasma spp. for the occurrence of CAM was 9.5 (1.10 –82) (p = 0.041). In very preterm birth infants with pPROM, CAM, BPD36, and NDIs occurred in 78, 60, and 36%, respectively. VaginalUreaplasma spp. was a significant risk...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research