Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

DiscussionThese findings demonstrate that chronic InRapa administration is able to exert a neuroprotective effect on Ts65Dn hippocampus by reducing AD pathological hallmarks and by restoring protein homeostasis, thus ultimately resulting in improved cognition. Results are discussed in term of a potential novel targeted therapeutic approach to reduce cognitive decline and AD-like neuropathology in DS individuals.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research