Effects of Asenapine and Paliperidone on Depression, Anxiety and Analgesy in Mice: Alterations in Brain Neurotrophic Factors, Neurogenesis, and Blood Enzyme Levels.

Effects of Asenapine and Paliperidone on Depression, Anxiety and Analgesy in Mice: Alterations in Brain Neurotrophic Factors, Neurogenesis, and Blood Enzyme Levels.
Chin J Physiol. 2018 Oct 31;
Authors: Gumuslu E, Mutlu O, Kokturk S, Ulak G, Eraldemir FC, Tatar OC, Yasar AB, Tanyeri P, Akar F, Erden F
Abstract
Schizophrenia, an important brain neurodevelopmental disorder, is observed in 1% of the
global population. New-generation antipsychotics have been developed as alternatives to typical
antipsychotics for more effective and safe therapy. Chronic administration of asenapine and
paliperidone compared to haloperidol on depression, anxiety and analgesy in the forced swimming
test (FST), elevated plus maze (EPM) and hot plate tests were examined in mice. Moreover effects
of drugs, on expression levels of brain neurotrophic factors [brain-derived neurotrophic factor
(BDNF), cAMP response element binding protein (CREB),nerve growth factor (NGF), synapsin and
fibroblast growth factor 2 (FGF2)] in the hippocampus of mice, neurogenesis and neurodegeneration,
and blood enzyme levels were also investigated. In FST, haloperidol (0.25 mg/kg) significantly
increased immobility time while both asenapine (0.075 mg/kg) and paliperidone (0.25 and 0.50 mg/kg)
significantly diminished this parameter. In EPM test, haloperidol significantly increased both % time
spent in open arms and % open arm entries. Asenapine (0.075 mg/kg) and paliperidone (0.50 m...

Source: The Chinese Journal of Physiology - November 3, 2018 Category: Physiology Tags: Chin J Physiol Source Type: research