Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice.

CONCLUSIONS: Oxidative stress might be one of the mechanisms of cisplatin- and paclitaxel-induced the loss of primordial follicles. Mangafodipir can reduce cisplatin- and paclitaxel-induced apoptosis in granulosa cells and primordial follicle activation partially via its SOD activity. At the same time, mangafodipir might have other potential mechanisms to inhibit the activation of primordial follicles. Further, mangafodipir attenuated the ovarian damage caused by cisplatin and paclitaxel without affecting their antitumor activities. Mangafodipir, therefore, though its efficacy might be limited, may be a new option for the preservation of fertility during anticancer treatment.
PMID: 30368246 [PubMed - in process]

Source: Reproductive Biology - October 27, 2018 Category: Reproduction Medicine Authors: Qin Y, Iwase A, Murase T, Bayasula, Ishida C, Kato N, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F Tags: Reprod Biol Endocrinol Source Type: research