New Research Initiative to Focus on Cerebrovascular Diseases

A multidisciplinary group of clinical and bench researchers has been formed at the University of Rochester Medical Center to study cerebrovascular disease. The Cerebrovascular and Neurocognitive Research Group (CNRG), which consists of faculty from Neurology, Neurosurgery, Electrical and Computer Engineering, Microbiology and Immunology, and Vascular Biology will leverage advanced brain imaging technologies to investigate a number of diseases, including stroke, cerebral small vessel disease, and vascular dementia.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news

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Cognitive impairment and dementia (CID) are major public health problems with substantial personal, social, and financial burdens. African Americans are at a heightened risk for Vascular Cognitive Impairment (VCI) compared to European Americans. Recent lines of evidence also suggest a high burden of Post-stroke VCI among indigenous Africans. A better understanding of the cause(s) of the racial disparity in CID, specifically VCI, is needed in order to develop strategies to reduce it.We propose and discuss the conceptual framework for a unique tri-population, trans-continental study titled The Vascular brain Injury Progressi...
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
The plants trap polluting particles like natural air filters, and protect against flooding, tooHedges and trees in towns and cities are more than just attractive, they can behave like natural air filters, trapping traffic pollution made up of dangerous microscopic particles blamed for a range of serious health problems, ranging from heart disease, asthma and strokes to diabetes, obesity and dementia.Astudy at Lancaster University showed that silver birch trees maintained as hedges at about the height of an adult person were particularly good at cleaning the air.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Trees and forests Air pollution Science Environment UK news University of Surrey Lancaster University Source Type: news
Whole organs are difficult to study in minute detail, as they have to be sliced into extremely thin sections to map out their interior. CT and magnetic resonance imaging help to an extent, but researchers at the Helmholtz Zentrum München, Ludwig...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials News Radiology Surgery Source Type: blogs
Conclusions: The results show a stepwise increase in mortality risk with increased BPSD, highlighting the importance of adequate management of BPSD to reduce mortality in dementia. PMID: 32067466 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
Microbleeds are a marker of cerebrovascular disease however its role in incident post-stroke dementia (PSD) remains unclear. We investigated whether microbleeds are associated with incident PSD, domain-specific cognitive impairment and cognitive decline over a 2-year follow-up; and whether microbleeds interact with acute stroke-related infarcts to synergistically affect cognitive outcomes. In a cohort of patients with first-episode mild ischemic stroke and no pre-stroke dementia, we found patients with 3 or more mixed microbleeds (presence of both lobar and deep) were 4 times more at risk of developing PSD compared to pati...
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
You notice your loved one becoming more forgetful. She cannot recall her visit with her granddaughters yesterday. She claims she took her medications this morning, yet you find them untouched in her pill case. You wonder how this mild-mannered woman has become so angry, so quickly. She is often frightened now, disoriented, and unpredictable. Yet she still remembers every detail of your wedding day, the names of your four children, and how to play her favorite piano pieces. When you sing together, time temporarily stands still. Your loved one received a diagnosis of Alzheimer’s disease. Nights are the hardest time for...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Caregiving Healthy Aging Memory Source Type: blogs
The small-vessel disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) arises from mutations in the human gene encoding NOTCH3 and results in vascular smooth muscle cell degeneration, stroke, and dementia. However, the structural changes in NOTCH3 involved in CADASIL etiology are unclear. Here, we discovered site-specific fragmentation of NOTCH3 protein in pathologically affected vessels of human CADASIL-affected brains. EM-based experiments to pinpoint NOTCH3 localization in these brains indicated accumulation of NOTCH3 fragmentation products in the basement membrane...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population. METHODS: A population-based nested case control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examine...
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
In this study, we established a prediction system to assess the risk of MCI among the elderly in China.MethodsThe Rothman-Keller model was conducted on the basis of the risk factors of MCI obtained by the combined results of a meta-analysis. The accuracy of the model was verified using actual population data.ResultsA total of 1826 subjects as a verification set were enrolled in this study in February 2019. There were statistically significant differences in the combined results of 10 risk factors including hypertension, diabetes, educational level, hyperlipidemia, smoking, physical exercise, living alone, stroke, drinking and heart disease (P
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
Abstract BACKGROUND: Leukoaraiosis (LA), widely accepted as a feature of cerebral small vessel disease, significantly increases the incidence of stroke, dementia, and death. Cerebral small artery disease has been considered as one of the main causes of LA. However, since the term "venous collagenosis" (VC) was proposed in an atrophy research in 1995, there have been pathological and neuroimaging studies proving the association between the venous system and LA in aging, Alz-heimer's disease (AD), and Parkinson's disease. SUMMARY: Autopsy studies confirmed that thickening of the lumen wall in venules,...
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research
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