Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice: implications for migraine

In this study, we report that peripherally administered CGRP can act in a light-independent manner to produce spontaneous pain in mice that is manifested as a facial grimace. As an objective validation of the orbital tightening action unit of the grimace response, we developed a squint assay using a video-based measurement of the eyelid fissure, which confirmed a significant squint response after CGRP injection, both in complete darkness and very bright light. These indicators of discomfort were completely blocked by preadministration of a monoclonal anti-CGRP–blocking antibody. However, the nonsteroidal anti-inflammatory drug meloxicam failed to block the effect of CGRP. Interestingly, an apparent sex-specific response to treatment was observed with the antimigraine drug sumatriptan partially blocking the CGRP response in male, but not female mice. These results demonstrate that CGRP can induce spontaneous pain, even in the absence of light, and that the squint response provides an objective biomarker for CGRP-induced pain that is translatable to humans.
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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ConclusionResults from our study supported the idea that the release of mPFC and NAc exosomes of CCI model has elevated the pain sensations in the subjected mice. This study will further help in designing new clinical trials, and will revolutionize the drug-induced anesthetic responses.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 22 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Joel Corbett, Sandeep Bhuta, Kerri Prain, Fabienne Brilot, Arman Sabet, Simon A. BroadleyAbstractA 33-year-old male presented with a progressive four-week history of frontal headache and left visual field impairment. MRI brain confirmed bilateral, asymmetric, occipital vasogenic oedema, suggestive of posterior reversible encephalopathy syndrome (PRES). Serum testing for MOG antibodies was positive, confirming a diagnosis of MOG antibody-related demyelination (MARD). A similar PRES-like pattern of white matter inflammation h...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Adults who experience pain are more likely to use cannabis without a prescription and have cannabis use disorder than those without pain, according to astudy published yesterday inAJP in Advance.“These results suggest that, among adults with pain, frequent nonmedical cannabis use and cannabis use disorder are growing problems,” wrote Deborah S. Hasin, Ph.D., of the New York State Psychiatric Institute and colleagues. “[T]he need remains for other interventions to manage pain that do n ot incur risk of another substance use disorder (i.e., cannabis use disorder) as an adverse treatment outcome.”Hasin...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance cannabis cannabis use disorder Deborah Hasin National Epidemiologic Survey on Alcohol and Related Conditions pain Source Type: research
CONCLUSIONS: The only sex difference was in SCM thickness. However, smaller SCMs in women did not result in less SCM SWE stiffness. We provided normative values for US-based imaging of the cervical-flexor and -extensor muscles in young and athletic men and women. PMID: 31967864 [PubMed - as supplied by publisher]
Source: Journal of Athletic Training - Category: Sports Medicine Tags: J Athl Train Source Type: research
ConclusionThere were excellent statistical connections between values of whiplash injury grade with muscle fatigue of paravertebral muscles and results of NDI questionnaire.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
CONCLUSIONS: The application of Hem-o-Lok clip during laparoscopic surgery is safe and effective. Postoperative Hem-o-Lok migration into the duodenum is rare. The treatment could be conservative in the majority of cases. PMID: 31958943 [PubMed - in process]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
CONCLUSION: Aortic stent graft combined with aneurysm embolization is a minimally invasive, effective and safe method for rBAA. PMID: 31964330 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
Authors: Kolbe L, Eberhardt T, Leinberger B, Hinterberger T Abstract BACKGROUND: Biofeedback-treatment for primary headache is highly recommended. Its expenses are mostly not or not completely covered by health funds, hindering the implementation in the care system. This randomized controlled study aimed at evaluating the efficacy of a biofeedback-treatment for primary headache in the outpatient care system all over Germany. METHODS: The participants were divided into a direct treatment-group (n=41) and a waiting control-group (n=29). The treatment was carried out for 8-11 sessions with vasoconstriction-/vasodi...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
Publication date: Available online 23 January 2020Source: Life SciencesAuthor(s): Myrna Déciga-Campos, Luis Alberto Melo-Hernández, Héctor Torres-Gómez, Bernhard Wünsch, Dirk Schepmann, María Eva González-Trujano, Josué Espinosa-Juárez, Francisco Javier López-Muñoz, Gabriel Navarrete-VázquezAbstractAimsHaloperidol is a neuroleptic drug with high affinity towards the σ1 receptor (σ1R), acting as antagonist that decreases neuropathic pain, but has CNS side effects. This work describes the design and synthesis of a novel analog N‑(...
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSION: Spontaneous resolution of lumbar ganglion is very rare and only 26 cases, including ours, were reported in literature. Different degrees of biomechanical impairment seem to play a fundamental role in the pathogenesis. Related symptoms are essentially represented by low back and/or radicular pain, without significant neurological disorders. Anti-inflammatory drugs, light unloading exercises and brace could be recommended to administrated pain and decrease facet loads. Mean time for clinical improvement was 7 mo, while MRI disappearance occurred in an average time of 11 mo. Therefore, surgery should be applied wh...
Source: World Journal of Orthopaedics - Category: Orthopaedics Tags: World J Orthop Source Type: research
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