Thrombophilic Genetic Anomalies and Their Association With Dialysis Initiation Age in a Cohort of Lebanese Hemodialysis Patients.

CONCLUSIONS: Our results revealed a polygenic thrombophilic profile in our population of Lebanese patients with end-stage renal disease. This profile showed a strong association between early dialysis initiation and specific homozygous cardiovascular disease gene mutations. The cumulative load of these genetic and traditional risk factors may be partly responsible for the increased risk of cardiovascular disease and risk of progression to end-stage renal disease in patients with chronic kidney disease. PMID: 30320542 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30320542?dopt=Abstract

Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - October 15, 2018 Category: Transplant Surgery Authors: Barbari A, Milane A, Salameh P, Abi Younis J, El Houjairy A, Safi K, Sabaa Ayoun I, Jaafar M, Bou Khalil L, Bachir A, Bassil N, Karnib H, Morad N, Rizk S, Masri M Tags: Exp Clin Transplant Source Type: research