285 * nanoliposomal-mediated sirna targeting of ea.hy926: a promising delivery method

Conclusion: We demonstrated that using optimal nanoliposomal complexes for effective human endothelial cell (Ea.hy926) targeting leads to high transfection efficiency and significant suppression of the protein level. Overcoming the siRNA extracellular instability with cell viability being unchanged shows that the developed delivery system may become a promising therapeutic strategy for non-small-cell lung carcinoma.

Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Nemeth, A., Nolte-Karayel, A., Stoleriu, M. G., Mustafi, M., Steger, V., Schlensak, C., Wendel, H. P., Walker, T. Tags: Basic science Source Type: research