Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo

ConclusionIn our study, albumin, manganese, cobalt and copper values did not differ between SCA children in steady state and Hb-AA children. The lack of differences in plasma elemental concentrations between the two groups in context of increased demands in the SCA group, may represent adequate compensatory intake or elemental dyshomeostasis in the SCA group.
Source: BMC Hematology - Category: Hematology Source Type: research

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Publication date: Available online 20 February 2020Source: Case Reports in Women's HealthAuthor(s): Antonella Iannaccone, Marvin Darkwah Oppong, Philipp Dammann, Rainer Kimmig, Angela KöningerAbstractA fetal subdural hematoma (SDH) was diagnosed in a patient with sickle cell disease (SCD) during a routine ultrasound exam in the 30th week of pregnancy. A scan performed a few days earlier had revealed no abnormalities. After interdisciplinary consultation with neurosurgeons and neonatologists, a cesarean section was performed since acute subdural bleeding was hypothesized and the mother's condition was critical. After s...
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
Date: Tuesday, 03 03, 2020; Speaker: John Tisdale, MD, NHLBI; Alan Schechter, MD, NIDDK; Building: Building 50; 1227/1233; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Conclusion: Endocrinopathy is a frequent complication of hemoglobinopathies, for which the most common were found to be short stature, diabetes mellitus,  and low bone mineral density. PMID: 32020146 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
The objective of this study is to reduce the morbidity of children with homozygous sickle cell disease presenting severe forms. We have conducted a longitudinal study between November 2015 and September 2017 at the Brazzaville University Hospital. Children with sickle cell disease requiring treatment with hydroxyurea were included. The variables studied were therapeutic compliance, evolutive profile of nutritional status, indications of hydroxyurea, electrophoresis of hemoglobin, blood count, and toxicity. The statistical test used was Student test with a significance threshold of less than 0.05. One thousand twe...
Source: Bulletin de la Societe de Pathologie Exotique - Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research
ConclusionIt clear that this study has successfully identified LCR mutations for random Saudi patients with SCD. The above results should be taken further to set up management strategies to improve outcomes.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Thalassemia major (TM) and sickle cell anemia (SCA) are the two most widespread inborn hemoglobinopathies worldwide. TM was the first congenital hemoglobinopathy to be cured by allogenic hematopoietic stem cell transplantation (HSCT),1 and SCA rapidly followed.2,3 Other than gene therapy,4 HSCT remains the only available curative treatment for these two diseases. Provided that an HLA-identical sibling donor is available, it should be performed as soon as possible for TM and in case of complications for SCA.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Contributors : Alexander Azzo ; Xiaofei Yu ; Mikhail Dozmorov ; Gordon D GinderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs high fetal hemoglobin (HbF) levels ameliorate the underlying pathophysiologic defects in sickle cell anemia and β-thalassemia, understanding the mechanisms that enforce silencing of HbF postnatally offers the promise of effective molecular therapy. Depletion of Methyl cytosine Binding Domain protein 2 (MBD2) causes a 10-20 fold increase in γ-globin gene expression in adult β-YAC transgenic mice. To determ ine the effect of MBD2 depletion in ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
(University of Washington Health Sciences/UW Medicine) 3D microvessels have been created to observe how red blood cells transit ultra-small blood vessels. They squeeze single-file through microvessels to bring oxygen and nutrients. Red cells burdened with malaria stall, blocking the blood vessel. The platform is expected to have other uses in studies of how microvascular damage occurs in diabetes and sickle cell anemia. They might be further developed to supply blood circulation to organ repair patches or to 3D printed transplants.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Georgia Institute of Technology) In diseases like cancer, atherosclerosis, and sickle cell anemia, cathepsins promote their propagation. Drug trials to inhibit these enzymes have failed due to baffling side effects. Now a new study examines cathepsins in systems to remove some of the bafflement.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Date: Tuesday, 04 14, 2020; Speaker: John Tisdale, MD, NHLBI; Alan Schechter, MD, NIDDK; Building: Building 50; 1227/1233; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
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