Indications for islet or pancreatic transplantation: Statement of the TREPID Working Group on behalf of the Soci été Francophone du Diabète (SFD), Société Francaise d'Endocrinologie (SFE), Société Francophone de Transplantation (SFT) and Société Française de Néphrologie-Dialyse-Transplantation (SFNDT).

Indications for islet or pancreatic transplantation: Statement of the TREPID Working Group on behalf of the Société Francophone du Diabète (SFD), Société Francaise d'Endocrinologie (SFE), Société Francophone de Transplantation (SFT) and Société Française de Néphrologie-Dialyse-Transplantation (SFNDT). Diabetes Metab. 2018 Sep 14;: Authors: Wojtusciszyn A, Branchereau J, Esposito L, Badet L, Buron F, Chetboun M, Kessler L, Morelon E, Berney T, Pattou F, Benhamou PY, Vantyghem MC Abstract While either pancreas or pancreatic islet transplantation can restore endogenous insulin secretion in patients with diabetes, no beta-cell replacement strategies are recommended in the literature. For this reason, the aim of this national expert panel statement is to provide information on the different kinds of beta-cell replacement, their benefit-risk ratios and indications for each type of transplantation, according to type of diabetes, its control and association with end-stage renal disease. Allotransplantation requires immunosuppression, a risk that should be weighed against the risks of poor glycaemic control, diabetic lability and severe hypoglycaemia, especially in cases of unawareness. Pancreas transplantation is associated with improvement in diabetic micro- and macroangiopathy, but has the associated morbidity of major surgery. Islet transplantation is a minimally invasive radiological or mini-surgical procedure involving infusi...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research