Quantity and Quality Reconstitution of NKG2A+ Natural Killer Cells Are Associated with Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment strategy for hematologic malignancies [1-6]. However, graft-versus-host disease (GVHD) is a common complication after allo-HSCT [7-10], resulting from the activation, amplification, and secretion of numerous inflammatory factors related to donor alloreactive T cells that damage host tissues and organs, mainly in the gastrointestinal tract, liver, and skin [11]. Notably, natural killer (NK) cells represent the first donor-derived lymphocyte population to recover after allo-HSCT and generally are observed within the first month after allo-HSCT [12].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research