Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide and the second cause of cancer-related deaths.[1] The vast majority of cases develop in patients with chronic liver diseases, the main risk factors being Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infection, alcohol intake and metabolic syndrome.[2,3] Clinical outcome remains poor, with approximately only one third of patients eligible to potentially curative treatments such as surgical resection, radiofrequency ablation or liver transplantation.

Source: Journal of Hepatology - September 10, 2018 Category: Gastroenterology Authors: Julien Calderaro, Florent Petitprez, Etienne Becht, Alexis Laurent, Th éo Z. Hirsch, Benoit Rousseau, Alain Luciani, Giuliana Amaddeo, Jonathan Derman, Cécile Charpy, Jessica Zucman-Rossi, Wolf Herman Fridman, Catherine Sautès-Fridman Source Type: research