Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Conclusions
Altogether, these cases add genetic and immunologic evidence to the novel association between defects in sensing of AT-rich DNA present in the VZV genome and increased susceptibility to severe manifestations of VZV infection in the CNS in humans.

Source: Neurology Neuroimmunology and Neuroinflammation - September 7, 2018 Category: Neurology Authors: Carter-Timofte, M. E., Hansen, A. F., Mardahl, M., Fribourg, S., Rapaport, F., Zhang, S.-Y., Casanova, J.-L., Paludan, S. R., Christiansen, M., Larsen, C. S., Mogensen, T. H. Tags: Vasculitis, Encephalitis, Viral infections, All Cerebrovascular disease/Stroke, All Genetics Article Source Type: research