Systemic complications of acromegaly and the impact of the current treatment landscape: an update.

Systemic complications of acromegaly and the impact of the current treatment landscape: an update. Endocr Rev. 2018 Aug 31;: Authors: Gadelha MR, Kasuki L, Lim DS, Fleseriu M Abstract Acromegaly is a chronic systemic disease with many complications and is associated with increased mortality when not adequately treated. Significant advances in acromegaly treatment, as well as in the treatment of many of its complications, mainly diabetes mellitus, heart failure and arterial hypertension, were achieved in the last decades. These developments allowed change in both prevalence and severity of some acromegaly complications and furthermore resulted in a reduction of mortality. Nowadays, mortality seems to be similar to the general population in adequately treated patients with acromegaly. In this review, we will update the knowledge in complications of acromegaly and detail the effects of different acromegaly treatment options on these complications. Incidence of mortality, its correlation with growth hormone (cumulative exposure vs last value) and insulin-like growth factor type I levels and the shift in the main cause of mortality in patients with acromegaly will be also addressed. PMID: 30184064 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research

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Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
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Source: Cytotherapy - Category: Cytology Source Type: research
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Source: Cytotherapy - Category: Cytology Source Type: research
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Source: Cytotherapy - Category: Cytology Source Type: research
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Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
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Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
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Source: Endocrine-Related Cancer - Category: Endocrinology Authors: Tags: Research Source Type: research
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