Cardiovascular risk in postmenopausal women with polycystic ovary syndrome.

Cardiovascular risk in postmenopausal women with polycystic ovary syndrome. Curr Vasc Pharmacol. 2018 Aug 28;: Authors: Lambrinoudaki I, Armeni E Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women of reproductive age. The hormonal alterations of PCOS have been linked with a higher risk of metabolic disturbances in young, reproductively active women. However, it remains to be clarified whether the presence of PCOS increases the risk of cardiovascular disease (CVD) later in life. Aging ameliorates the clinical manifestations of PCOS; hyperandrogenaemia and metabolic abnormalities, however, persist beyond the menopause. On the other hand, aging and menopause increase CVD risk in the general female population. The results of the limited available studies in aging women with a previous diagnosis of PCOS demonstrate early atherosclerosis. However, studies addressing clinical CVD outcomes in women with PCOS report inconsistent findings. A possible explanation for this heterogeneity is the difficulty in diagnosing PCOS after the menopausal transition, due to the absence of validated diagnostic criteria for this population. Larger prospective studies of women diagnosed during their reproductive years will shed more light on the longer-term CVD implications of PCOS. PMID: 30156159 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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Congratulations to the winners of the 2020 Society for EndocrinologyUndergraduate Video Award. This new Society award challenged students to produce a 1-2 minute video, aimed at engaging the general public with endocrinology. Communicating science to wider audiences is an important skill for every scientist and the standard of submissions was very high. You can watch the winners and highly commended runners up on ourdedicated You and Your Hormones webpage. 1st Place Our Bodies May Cure Themselves of Diabetes in the Future Aqua Asif, University of Leicester2nd Place Why does hot flushing occur in menopause? Carmen Ho, ...
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Abstract It is well known that stroke incidence and outcome is sex-dependent and influenced by age and gonadal hormones. In post-menopausal and/or aged females, declining estrogen levels increases stroke risk. However, women who experience early menopause also have an increase in stroke risk. This suggests that, regardless of age, gonadal hormones regulate stroke risk and severity. This review discusses prolonged gonadal hormone dysfunction in a common female endocrine disorder known as polycystic ovarian syndrome, PCOS, and the associated increased risk of stroke due to resulting hyperandrogenism and metabolic co...
Source: Frontiers in Neuroendocrinology - Category: Endocrinology Authors: Tags: Front Neuroendocrinol Source Type: research
ann Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. In contrast, there is a growing body of evidence for a protective role of oral contraceptives. Most of the published data...
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Abstract Endogenous and exogenous hormones have significant effects on coagulation and may tip the hemostatic balance toward thrombosis. The endogenous hormonal changes in pregnancy and polycystic ovary syndrome, and exogenous hormonal contraception, menopause replacement, and transgender cross-hormone replacement may increase thromboembolism risk. Using the lowest effective dose is critical for prevention, but once thrombosis occurs, anticoagulation may be required, in some, long-term. We review the relative risk of thrombosis in these con...
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Tags: Transl Res Source Type: research
Endogenous and exogenous hormones have significant effects  on coagulation and may tip the hemostatic balance toward thrombosis. The endogenous hormonal changes in pregnancy and polycystic ovary syndrome, and exogenous hormonal contraception, menopause replacement, and transgender cross-hormone replacement may increase thromboembolism risk. Using t he lowest effective dose is critical for prevention, but once thrombosis occurs, anticoagulation may be required, in some, long-term. We review the relative risk of thrombosis in these conditions, risk fa...
Source: Translational Research - Category: Research Authors: Tags: Review Article Source Type: research
Authors: Della Corte L, Foreste V, Barra F, Gustavino C, Alessandri F, Centurioni MG, Ferrero S, Bifulco G, Giampaolino P Abstract INTRODUCTION: Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 8-13% of reproductive-age women. Irregular periods, hirsutism, or infertility are the most common clinical presentations of patients affected by PCOS. This syndrome is also linked to metabolic abnormalities such as type 2 diabetes, insulin resistance and obesity. The optimal therapeutic approach is still unknown. AREAS COVERED: This narrative review offers an overview of the literature on current an...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Depending on the diagnostic criteria used and the population studied, its prevalence ranges between 4-21% [1,2]. According to the widely accepted 2003 Rotterdam criteria, PCOS diagnosis requires at least two of the following three features: oligo-anovulation (OA), clinical/biochemical hyperandrogenism (HA) and presence of polycystic ovarian morphology (PCOM) on ultrasonography [3]. Based on the presence and/ or absence of these diagnostic features, different phenotypes have been identified (Table 1).
Source: Maturitas - Category: Primary Care Authors: Source Type: research
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Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
z Senkal This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary inconti...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
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