Partial splenic embolization in the treatment of prolonged thrombocytopenia due to hypersplenism in metastatic cancer patients

ConclusionsPSE can be considered as a treatment option for HST.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research

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In this study, five population databases plus the Catalog of Somatic Mutations in Cancer was employed to demonstrate the impact of changing the PF cut-off on assignment of variants as germline versus somatic. The 1% to 2% PF cut-offs widely used in bioinformatic pipelines result in high sensitivity for classification of somatic variants, but unnecessarily reduced sensitivity for germline variants. Using optimized PF cut-offs, the source of variants in TCGA data could be predicted with>95% accuracy. Further exploration of four TCGA cancer datasets indicated that the optimal cut-off is influenced by both cancer type and t...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: Available online 25 June 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Paolo A. Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, Nikoletta SidiropoulosAn enduring goal of personalized medicine in cancer is the ability to identify patients who are likely to respond to specific therapies. Our growing understanding of the biology and molecular signatures of individual tumor types has facilitated the identification of predictive biomarkers and has led to an increasing number of diagnostic tests to be performed, often as serial and distinct assays on limited tumor specimens. The biomark...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
ConclusionsNon-JIA diagnosis, older age, and ANA-negativity were associated with symptomatic first-U in our study cohort, but no patient characteristics were significantly associated with symptomatic recurrence. Clinical patterns may change during disease course, with uveitis switching from symptomatic to asymptomatic, which has implications for uveitis monitoring recommendations.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
ConclusionCO2 absorption rates, anesthesiologists’ ability to maintain adequate etCO2, and postoperative shoulder pain did not differ based on insufflation system type or IAP. Surgeons’ rating of visualization of the operative field was significantly improved when using the valveless over the standard insufflation system.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 25 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Rodger Rothenberger, Amanda Jackson, Ady Kendler, Thomas Herzog, Caroline BillingsleyAbstractPerivascular epithelioid cell neoplasms (PEComas) are mesenchymal neoplasms originating from the perivascular epithelioid cell (PEC) line. The World Health Organization (WHO) further defines PEComa as “a mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells”. Gynecologic PEComas account for approximately ¼ of the PEComa cases reported in the literature and are h...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Objective The aim of this study was to use an electronic tablet–based education module to increase patient knowledge about human papillomavirus (HPV). Methods Patients presenting to an academic colposcopy clinic were first queried as to whether they had been infected with HPV. A quality improvement project was then conducted using a 4-question pretest assessing baseline knowledge about HPV and cancer, followed by a tablet-based education module and a 5-question posttest. Results Between June 2017 and January 2018, 119 patients participated in the tablet education. At their initial visit, only 50 (42.0%) of pa...
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research
Conclusions Both methods of sampling were found to be acceptable to women. Self-sampling is cost-effective and could increase the screening coverage among underscreened populations. However, more information about the quality, reliability, and accuracy of self-sampling is needed to increase women's confidence about using to this method.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research
No abstract available
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Forum Source Type: research
Conclusions Wearing tight-fitting jeans or pants and removing hair from the mons pubis area were associated with increased odds of vulvodynia. Research on how hygienic practices could influence vulvar pain in larger and more temporally addressed populations is warranted.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Vulva and Vagina Source Type: research
This study aimed to investigate pediatricians’ and general practitioners’ (GPs) advising practices and perceived familiarity of probiotics in the management of FAPDs and FDD. A cross-sectional survey was administered to Dutch pediatricians and GPs, including 27 questions about perceived familiarity of probiotics, followed by questions related to advising practices and reasons for advising or not advising probiotics. The responses of 319 pediatricians and 67 GPs were included. Significantly more pediatricians indicated to be familiar with probiotics compared to GPs (71% vs. 48% respectively, p 
Source: PharmaNutrition - Category: Nutrition Source Type: research
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