Quantity and Quality Reconstitution of NKG2A+ NK cells Are Associated with Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment strategy for hematological malignancies.1-6 However, graft-versus-host disease (GVHD) is a common complication after allo-HSCT 7-10 resulting from the activation, amplification and secretion of numerous inflammatory factors related to donor alloreactive T cells that damage host tissues and organs, mainly in the gastrointestinal tract, liver and skin.11 Notably, natural killer (NK) cells represent the first donor-derived lymphocyte population to recover after allo-HSCT and generally are observed within the first month after allo-HSCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research