Decoupling between Diastolic Pulmonary Artery Pressure and Pulmonary Artery Wedge Pressure at Incremental LVAD speeds is Associated with Worse Prognosis following LVAD Implantation

Pulmonary hypertension (PH) is one of the critical comorbidities in advanced heart failure (HF).1,2 Indices of PH such as mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), and trans-pulmonary artery pressure gradient improve following left ventricular assist device (LVAD) implantation mainly due to left ventricular unloading.3,4 Several investigators demonstrated in small cohorts that patients whose elevated PVRs were normalized following LVAD implantation had comparable post-heart transplant survival rates to those without PH.

Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Teruhiko Imamura, Gene Kim, Jayant Raikhelkar, Nitasha Sarswat, Sara Kalantari, Bryan Smith, Daniel Rodgers, Ben Chung, Ann Nguyen, Takeyoshi Ota, Tae Song, Colleen Juricek, Valluvan Jeevanandam, Daniel Burkhoff, Gabriel Sayer, Nir Uriel Tags: Clinical Investigation Source Type: research