Cancers, Vol. 10, Pages 267: The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma

Cancers, Vol. 10, Pages 267: The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers10080267 Authors: Marc Hamoir Sandra Schmitz Carlos Suarez Primoz Strojan Kate A Hutcheson Juan P Rodrigo William M Mendenhall Ricard Simo Nabil F Saba Anil K D‘Cruz Missak Haigentz Carol R Bradford Eric M Genden Alessandra Rinaldo Alfio Ferlito Chemoradiotherapy has emerged as a gold standard in advanced squamous cell carcinoma of the head and neck (SCCHN). Because 50% of advanced stage patients relapse after nonsurgical primary treatment, the role of salvage surgery (SS) is critical because surgery is generally regarded as the best treatment option in patients with recurrent resectable SCCHN. Surgeons are increasingly confronted with considering operation among patients with significant effects of failed non-surgical primary treatment. Wide local excision to achieve clear margins must be balanced with the morbidity of the procedure, the functional consequences of organ mutilation, and the likelihood of success. Accurate selection of patients suitable for surgery is a major issue. It is essential to establish objective criteria based on functional and oncologic outcomes to select the best candidates for SS. The authors propose first to understand preoperative prognostic factors influencing survival. Predictive modeling based on preoperative information is now available to better select patients h...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research