MELK inhibition in Diffuse Intrinsic Pontine Glioma.

CONCLUSION: We show a strong preclinical effect of the kinase inhibitor OTSSP167 in the treatment of DIPG and identify the MELK-PPARγ signaling axis as a putative therapeutic target in this disease.
PMID: 30061363 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - July 30, 2018 Category: Cancer & Oncology Authors: Meel MH, de Gooijer MC, Guillén Navarro M, Waranecki P, Breur M, Buil L, Wedekind LE, Twisk JWR, Koster J, Hashizume R, Raabe EH, Montero Carcaboso A, Bugiani M, van Tellingen O, van Vuurden DG, Kaspers GJL, Hulleman E Tags: Clin Cancer Res Source Type: research