Antiviral with HDAC inhibitor: A Combined Approach Targeting Hepatocellular Carcinoma by HCV

Background: In Patna city of Bihar region, India in HCV claims to be one of the rapid growing viral diseases during the last five year studies. Hepatocellular carcinoma is a viral disease that chronically infects human and other mammals worldwide. It leads to serious cirrhosis, hepatitis cancer, hepatitis failure and liver fibrosis in humans. Drugs targeted viral proteins of HCV lifecycle (NS3/4A protease, NS5B polymerase and NS5A protein). Resistance against the most promising protease inhibitors, telaprevir, boceprevir, and ITMN-191 has emerged in clinical trials.

Source: International Journal of Infectious Diseases - July 27, 2018 Category: Infectious Diseases Authors: G. Sahoo, P. Das, V. Rabidas, R. Topno, R. Kumar, K. Pandey Tags: UMP. 750 Source Type: research