Brain Atrophy and Cognitive Impairment in Chronic Kidney Disease.

Brain Atrophy and Cognitive Impairment in Chronic Kidney Disease. Contrib Nephrol. 2018;196:27-36 Authors: Tsuruya K, Yoshida H Abstract BACKGROUND: There is an increasing prevalence of dementia associated with population aging, and anti-dementia measures have now become of increasing importance in Japan. Chronic kidney disease (CKD) is a risk factor for cognitive impairment. SUMMARY: We previously demonstrated that hemodialysis patients have a higher prevalence of brain atrophy, even at younger age, than the general population, and also demonstrated the association between frontal lobe atrophy and frequency of rapid decline in blood pressure during the hemodialysis session. Recently, we demonstrated that decline in gray matter volume in CKD patients on peritoneal dialysis was significantly more rapid compared to non-dialysis-dependent CKD patients, and also showed a close association between gray matter atrophy and executive dysfunction in CKD patients, suggesting the importance of preventing brain atrophy for the prevention of cognitive impairment. Our recent epidemiological study demonstrated that both decreased kidney function and albuminuria were identified as independent risk factors for the development of dementia. In addition, it has been reported that possible contributing factors include anemia, oxidative stress, and the renin-angiotensin system (RAS). Previous reports have demonstrated that CKD patients with severe anemia show cognitive imp...
Source: Contributions to Nephrology - Category: Urology & Nephrology Tags: Contrib Nephrol Source Type: research

Related Links:

Certain fats found in seafood may help keep you healthy for years to come, according to a new study published in the BMJ. Higher blood levels of omega-3 polyunsaturated fatty acids — healthy fats found in foods such as fish, nuts, leafy greens and vegetable and flaxseed oils — were associated with a greater chance of healthy aging, according to the observational research. Omega-3s found in seafood seemed to have the strongest effect, says study co-author Heidi Lai, a postdoctoral fellow at Tufts’ Friedman School of Nutrition Science and Policy. “There had been studies that looked at the relationship...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime Source Type: news
CONCLUSION: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients. PMID: 30326480 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Li Y, Xia R, Zhang B, Li C Abstract Chronic atrophic gastritis is a generally asymptomatic condition of great importance because it develops into gastric cancer in a number of patients. It is described as an atrophy of the gastric mucosa. There are two types of atrophic gastritis: a gastric body predominant type in patients with infection of Helicobacter pylori, and an autoimmune type, limited to the gastric body and fundus. The autoimmune type is quite rare and affects people of all ethnicities. Globally, H. pylori infection is very common and is considered a class I carcinogen due to the large number of ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research
Publication date: Available online 16 October 2018Source: Alzheimer's &DementiaAuthor(s): Tim Wilkinson, Kathryn Bush, Cathie L.M. Sudlow
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 16 October 2018Source: Alzheimer's &DementiaAuthor(s): Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, José-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina SavichevaAbstractIntroductionReimbursement of amyloid-PET is lagging due to the lack of definitive evidence on its clinical utility and cost-effectiveness. The Amyloid Imaging to Preven...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Caring for a person living with Alzheimer's is difficult. Sometimes you just don't know what to do. Imagine my mother saying to me - "get out, I can take care of myself". Imagine what that felt like?I took care of my mother, Dotty, for eight and a half years, 3,112 days.I know what itfeels like to be a caregiver.I understand.One of the biggest, most hurtful problems I faced was when she would tell me -"get out, I don't need you, I can take care of myself".There I was. I had quit my job, dropped out of the world,and I was taking care of her 24 hours a day, seven days a week. When she said those words it ...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimers care alzheimers mother calm an alzheimer's patient dementia care family alzheimers health help alzheimer's mom Source Type: blogs
This study evaluates the incidence of hypoglycemia in the first 72 h of postoperative and its association with different factors, such as tissue perfusion parameters, and the administration of medicines that induct hypoglycemia during surgery, in patients that undergo cardiovascular surgery in a 4th level hospital in Bogota, Colombia.Methods and materialsA nested cases and controls study was developed, taking as cases the patients that presented hypoglycemia episodes (
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
CONCLUSIONS: The decrease in RI suggests a better resolution at primary care. The major improvement in the Basic Health Areas of reference (with RI reduced by more than 44%) coincides with the implementation of the ONP. The implantation of ONP overcome the gap between primary and hospital care in order to respond to chronicity, aging and dependence. PMID: 30318279 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Clinical trials looking at the safety and efficacy of glucose-lowering agents in patients with chronic kidney disease (CKD) and diabetes will be center stage at Kidney Week 2018.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
The science we conduct often reflects the society we live in. One phenomenon of current society is the rise of the reality television show. Participants are promised instant media fame without having to struggle through acting school. I worry that this has rubbed off on some of the studies we now conduct. Sir Richard Doll and Austin Hill, the architects of modern epidemiology, realized that it was hard for epidemiology to prove or disprove anything. Their studies were driven by clear hypotheses as some took five to 10 years to complete. Furthermore, their landmark paper on smoking and lung cancer devoted over a page of dis...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Conditions GI Source Type: blogs
More News: Anemia | Antidoxidants | Brain | Chronic Kidney Disease | Dementia | Dialysis | Epidemiology | Hemodialysis | Japan Health | Neurology | Peritoneal Dialysis | Study | Urology & Nephrology