Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma.

CONCLUSIONS: High TACC3 expression was associated with aggressive clinicopathologic features and unfavorable prognosis in these patients with osteosarcoma. Our preliminary results suggest that further analysis about mutation or an inactive form of TACC3 would be useful to understand the mechanism of abnormal TACC3 expression in patients with osteosarcoma. If these findings are substantiated in larger studies, TACC3 might be useful for predicting survival and a potential therapeutic target for osteosarcoma.
LEVEL OF EVIDENCE: Level III, therapeutic study.
PMID: 30024460 [PubMed - as supplied by publisher]

Source: Clinical Orthopaedics and Related Research - July 13, 2018 Category: Orthopaedics Authors: Matsuda K, Miyoshi H, Hiraoka K, Hamada T, Nakashima K, Shiba N, Ohshima K Tags: Clin Orthop Relat Res Source Type: research