Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human Heart Failure with Preserved Ejection Fraction.

In conclusion, the db/db mouse model recapitulates functional and histological features of human HFpEF associated with metabolic dysfunction. Development of fibrosis in db/db hearts, in the absence of myofibroblast conversion suggests that metabolic dysfunction may activate an alternative pro-fibrotic pathway associated with accentuated extracellular matrix protein synthesis. PMID: 30004258 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research