Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat.

In conclusion, CUMS-induced depression- and anxiety-like behavior may result from imbalance between M1 and M2 and suppressed astrocyte function since minocycline treatment reversed M1 response, which was associated with behavioral normalization. PMID: 30003978 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30003978?dopt=Abstract

Source: Behavioural Brain Research - July 9, 2018 Category: Neurology Authors: Zhang C, Zhang YP, Li YY, Liu BP, Wang HY, Li KW, Song C Tags: Behav Brain Res Source Type: research