Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis.

CONCLUSION: TPL could improvearthritic of TNF-Tg mice by decreasing the levels of pro-inflammatory cytokines, promoting the apoptosis of OCP, inhibiting the generation of OC and bone resorption. There was some toxic and side effect on liver for high-dose TPL which was weaker than the MTX.
PMID: 29990875 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2018 Category: Drugs & Pharmacology Authors: Wang S, Zuo S, Liu Z, Ji X, Yao Z, Wang X Tags: Biomed Pharmacother Source Type: research