Sex, pregnancy, and age-specific differences of blood manganese levels in relation to iron status; what does it mean?

In conclusion, the differences between a physiological and a pathological hypermanganesemia complicate interpretation of the dose-response relationship.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research

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Discussions about sexuality and reproduction are an important part of transition planning and must be done with an awareness of the adolescent’s developing understanding and maturity. Pregnancy imposes a hemodynamic load on the heart which may lead to cardiac, obstetric and fetal/neonatal complications in women with CHD. Pre-pregnancy counselling must include an assessment of maternal and fetal risk according to several well-developed models. Counselling should also include discussions about fertility and alternatives to pregnancy when appropriate. Recommendations for contraception must be made according to the patie...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
AbstractDopamine agonists (DAs) are well recognized as the first-line therapy for prolactinomas due to their efficacy in achieving tumoral shrinkage and normoprolactinemia. However, it remains to be established the best timing to withdraw DAs and in which patients this should be attempted. Studies in the 1980s, mainly using bromocriptine, started to defy the concept that DAs should be regarded as a lifelong therapy considering that sustained normoprolactinemia was attained in a small subset of patients after drug withdrawal. The introduction of the more effective agent cabergoline led to an increase in the percentages of r...
Source: Pituitary - Category: Endocrinology Source Type: research
Authors: Meudal J, Sabbagh O, Lejoyeux M PMID: 31522834 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Authors: Friedman SH, Tamburello AC, Kaempf A, Hall RCW Abstract Prescribing for women in jails and prisons requires special consideration and should be informed by extant evidence. Incarcerated women have higher rates of mental illness than both females in the community and incarcerated men. Medication administration concerns that may disproportionately affect female prisoners include drug-drug interactions with contraceptives, intermittent dosing schedules, and concerns about metabolic side effects. Further, pregnancy, lactation, and menopause may all affect medication choices. Incarcerated women frequently have ...
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
The North American Menopause Society (NAMS) held the 2018 Utian Translational Science Symposium on October 2, 2018, in San Diego, California, to discuss new therapeutic approaches to uterine leiomyomas when surgery is not the optimal choice. Uterine leiomyomas arise from a single clonal cell and are the most common gynecologic disorder affecting reproductive and perimenopausal women worldwide. The prevalence of this disorder is approximately 40% to 70% in white women and 60% to 80% in black women. Recent research suggests that both estrogen and progesterone modulate the growth of leiomyomas, with progesterone being a majo...
Source: Menopause - Category: OBGYN Tags: NAMS Translational Science Symposium Report Source Type: research
Objective: We aimed to investigate whether the number of pregnancies during childbearing age was associated with diabetes in postmenopausal women with no history of gestational diabetes. Methods: Our data source was the continuous National Health and Nutrition Examination Survey 1999 to 2014. We selected 9,138 postmenopausal women over 40 years old who did not have a history of gestational diabetes during pregnancy. Logistic regression analyses were applied for the association of the number of pregnancies with diabetes. Results: We found women with ≥4 pregnancies had significantly greater fasting plasma glucose ...
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Abstract Every age group experiences back pain, a common reason for activity limitation. Management of back pain in a woman is challenging because of physiologic and hormonal changes through the woman's life cycle. The treatment is dictated by etiology and a woman's stage of life or reproductive events, such as pregnancy, breastfeeding, and menopause. Most episodes of low back pain are temporary with minimal long-term sequelae, but recurrent and long-lasting episodes require more thorough clinical evaluation. This monograph describes the anatomy of the spine; illustrates a focused, thorough evaluation, including o...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
In conclusion, we identified specific Lactobacillus strains able to interfere with GBS viability by multiple strategies and we elucidated some of the mechanisms of action. These strains could serve as probiotic formulations for the prevention of GBS vaginal colonization.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, we assess safety, efficacy, and anti-aging endpoints of an OTC 3-step anti-acne skin regimen in a population of adult women with AV.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
CONCLUSIONS: Breastfeeding represents a protective mechanism only in patients without genetic breast cancer predisposing mutations. Environmental and reproductive factors can impact the risk and the age of onset of breast cancer in patients carrying pathogenic mutations, but the mechanisms of action are not fully understood. PMID: 31424662 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
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