Sex-mediated response to landiolol, a ß1 selectif adrenergic blocker, in myocardial dysfunction during sepsis

ConclusionLandiolol improved the in vivo cardiac performance of septic male rats, in association with an improvement in diastolic function. However, in septic females, treatment with landiolol resulted in deleterious effects. Ongoing analysis of these signaling pathways will aid better understanding of sex differences occurring in sepsis.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research