Probiotic Lactobacillus paracasei HII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 (Oat3) function

In conclusion, probiotic supplementation alleviated kidney inflammation, ER stress, and apoptosis, leading to improved kidney function and renal Oat3 function in obese rats.  These benefits involve the attenuation of hyperlipidemia, systemic inflammation and insulin resistance.  This study also suggested the idea of remote sensing and signaling system between gut and kidney by which probiotic might facilitate renal handling of gut microbiota products through the improvement of Oat3 function.

Source: Clinical Science - July 6, 2018 Category: Biomedical Science Authors: Wanchai, K., Yasom, S., Tunapong, W., Chunchai, T., Eaimworawuthikul, S., Thiennimitr, P., Chaiyasut, C., Pongchaidecha, A., Chatsudthipong, V., Chattipakorn, S., Chattipakorn, N., Lungkaphin, A. Tags: PublishAheadOfPrint Source Type: research