Release of MicroRNAs into Body Fluids from Ten Organs of Mice Exposed to Cigarette Smoke

Conclusions: microRNA expression analysis was able to identify target organs after just 8 weeks of exposure to smoke, well before the occurrence of any detectable histopathological alteration. The present translational study validates the use of body fluid microRNAs as biomarkers applicable to human biomonitoring for mechanistic studies, diagnostic purposes, preventive medicine, and therapeutic strategies.

Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Alberto Izzotti, Mariagrazia Longobardi, Sebastiano La Maestra, Rosanna T. Micale, Alessandra Pulliero, Anna Camoirano, Marta Geretto, Francesco D'Agostini, Roumen Balansky, Mark Steven Miller, Vernon E. Steele, Silvio De Flora Tags: Research Paper Source Type: research