HIV and Symptoms of Depression are Independently Associated with Impaired Glucocorticoid Signaling

Advances in antiretroviral therapy (ART) have dramatically increased the life expectancy of people living with HIV (PLWH); however, PLWH still suffer from inflammation-related diseases such as cardiovascular disease, type II diabetes, cancer, and dementia at higher rates and at younger ages than uninfected individuals (Nemeth et al 2015, Valdez et al 2016). Although it has been established that persistent immune activation and inflammation contribute to non-AIDS pathologies in PLWH who are on suppressive antiretroviral therapy (ART) (Hunt 2012), the factors contributing to sustained inflammation in otherwise healthy PLWH have not been identified.

Source: Psychoneuroendocrinology - June 18, 2018 Category: Psychiatry Authors: Mandakh Bekhbat, C. Christina Mehta, Sean D. Kelly, Aimee Vester, Igho Ofotokun, Jennifer Felger, Gina Wingood, Kathryn Anastos, Deborah R. Gustafson, Seble Kassaye, Joel Milam, Brad Aouizerat, Kathleen Weber, Elizabeth T. Golub, Michelle Floris Moore, Ra Source Type: research