Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma
Esophageal cancer (EC) is the 6 t h leading cause of cancer mortality worldwide with poor prognosis, hence more effective chemotherapeutic drugs for this deadly disease are urgently needed. We previously reported that high expression of Orai1, a store-operated Ca2+entry (SOCE) channel was associated with poor survival rate in EC patients and Orai1-mediated intracellular Ca2+ oscillations regulated cancer cell proliferation. Previous studies suggested that Orai1-mediated SOCE is a promising target for EC chemotherapy.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Chaochu Cui, Yan Chang, Xiaoli Zhang, Sangyong Choi, Henry Tran, Kumar V. Penmetsa, Srikant Viswanadha, Liwu Fu, Zui Pan Tags: Original Articles Source Type: research
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