Metabolic Complications in Adrenal Insufficiency.
Metabolic Complications in Adrenal Insufficiency. Front Horm Res. 2018;49:104-113 Authors: Ueland GA, Husebye ES Abstract Pharmacological glucocorticoid treatment is associated with adverse metabolic consequences such as hypertension, overweight, reduced glucose tolerance, diabetes mellitus and ultimately increased mortality in cardiovascular disease. Here we review the evidence of detrimental effects of hormone replacement therapy in adrenal insufficiency (AI). Registry studies indicate increased cardiovascular mortality, hypertension, diabetes, and dyslipidemia in both primary and secondary AI, but when cohorts with carefully characterized patients are studied the picture is less clear, and recently patients with primary AI was reported to have less hypertension and lower body mass index than controls. Whether near physiological replacement therapy increase long-term cardiovascular morbidity and mortality in AI is still unclear. PMID: 29894991 [PubMed - in process]
Researchers at the University of Guelph in Ontario, Canada claim the whey and casein proteins in cow's milk make people feel full and release hormones which reduce blood sugar.
DIABETES type 2 symptoms can be hard to spot and many people with the condition won ’t realise they have it. But if this type of diabetes is left untreated it can lead to more serious health problems. Drinking certain types of alcohol can cause blood sugar levels to spike.
In an intriguing study, black patients were far more likely to agree to certain health tests if they discussed them with a black male doctor.
A new study evaluates the management of emergency situations in patients with chronic adrenal insufficiency.Clinical Endocrinology
(Elsevier) A change in breakfast routine may provide benefits for the management of type 2 diabetes, according to a new study published in the Journal of Dairy Science. A team of scientists found that milk consumed with breakfast cereal reduced postprandial blood glucose concentration compared with water, and high dairy protein concentration reduced postprandial blood glucose concentration compared with normal dairy protein concentration. The high-protein treatment also reduced appetite after the second meal compared with the low-protein equivalent.
Changes in the levels of rennin, angiotensin II, and angiotensin (1 –7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7 ±1.2 to 14.7±1.9 pg/ml (p=0.019). On the contrary, angiotensin (1 –7) concentration decreased from 771.1±44.2 to 390.7±13.9 pg/ml (p
In this study, twelve test cases were presented and by applying lazy snapping algorithm, the hottest or coldest regions were extracted from the corresponding body thermographic images. The time taken to see the results varied from 7 to 30 s for these twelve cases. It was concluded that lazy snapping was much faster than other methods applied by the authors such asK-means, fuzzyc-means, level set, and mean shift algorithms for segmentation.Graphical abstractTime taken to implement lazy snapping algorithm to extract suspicious regions in different presented thermograms (in seconds). In this study, ten test cases are pr...
AbstractA seven-months-old girl under treatment for pneumonia presented with generalized edema, decreased urinary output and was found to have hypertension, muco-cutaneous fungal infection and pulmonary hypertension. Investigations revealed that she had heavy proteinuria, hypertriglyceridemia, hypoalbuminemia and elevated levels of free T3 and T4 with suppression of TSH levels in the serum. A diagnosis of autoimmune thyroiditis (AT) in thyrotoxic phase was made on the basis of clinical presentation and presence of anti-TPO antibodies and reduced uptake in thyroid (technetium) scintigraphy. The child responded to carbimazol...
ConclusionSurgeons must have high index of suspicion for elderly obese males with inguinal hernias and urinary or intestinal obstruction symptoms. Careful preoperative planning must be made to avoid repair associated bladder injuries.
Background: Glucocorticoid replacement is commonly required to treat secondary adrenal insufficiency after surgical resection of unilateral cortisol-secreting adrenocortical adenomas. Here, we describe a patient with unilateral cortisol-secreting adenomas in which the preoperative use of mifepristone therapy was associated with recovery of the hypothalamic–pituitary–adrenal (HPA) axis, eliminating the need for postoperative glucocorticoid replacement. Case Presentation: A 66-year-old Caucasian man with type 2 diabetes mellitus, hyperlipidemia, hypertension, and obesity was hospitalized for Fournier’s gan...