Metabolic Complications in Adrenal Insufficiency.
Metabolic Complications in Adrenal Insufficiency. Front Horm Res. 2018;49:104-113 Authors: Ueland GA, Husebye ES Abstract Pharmacological glucocorticoid treatment is associated with adverse metabolic consequences such as hypertension, overweight, reduced glucose tolerance, diabetes mellitus and ultimately increased mortality in cardiovascular disease. Here we review the evidence of detrimental effects of hormone replacement therapy in adrenal insufficiency (AI). Registry studies indicate increased cardiovascular mortality, hypertension, diabetes, and dyslipidemia in both primary and secondary AI, but when cohorts with carefully characterized patients are studied the picture is less clear, and recently patients with primary AI was reported to have less hypertension and lower body mass index than controls. Whether near physiological replacement therapy increase long-term cardiovascular morbidity and mortality in AI is still unclear. PMID: 29894991 [PubMed - in process]
Conclusions: Social support was identified as an important variable for older adults with chronic illness who lived alone. Interventions that include social support hold the potential to reduce depression and suicidal ideation in this population.
Could a parent-led, home-based physical activity intervention lead to improvements in exercise participation?Medicine and Science in Sports and Exercise
Publication date: Available online 19 May 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Tao Tao, Yuying Wang, Bing Xu, Xiuying Mao, Yun Sun, Wei LiuAbstractImpaired steroid production in polycystic ovary syndrome (PCOS) may result from adiponectin system dysfunction. However, adiponectin's role in ovulatory dysfunction remains unclear. We aimed to determine whether human chorionic gonadotropin (hCG) and adiponectin affect progesterone and estradiol secretion by granulosa cells (GCs) from overweight or obese women with PCOS or normal ovulation. ADIPOR2 expression was higher in hCG-treated GCs from PCOS patients...
Adrienne Kennedy of the National Alliance on Mental Health (NAMI) shares the story of losing her son due to type 1 diabetes and mental health issues.
No abstract available
CONCLUSIONS: Although significance was not established because of sample size, there was a definite trend toward significance that merits further investigation with human amniotic allograft.
The first randomized controlled trial to demonstrate that a diet high in ultra-processed foods leads to greater calorie intake and weight gain has been published, albeit in a tiny number of volunteers.Medscape Medical News
Conclusion: The proposed depth-resolved MWPPG method can provide accurate measurements of SVR and BP, which are traditionally difficult to measure in a noninvasive or continuous fashion. Significance: This MWPPG work provides the wearable healthcare electronics of compact size with a low-cost and physiology-based solution for continuous measurement of BP and SVR.
Publication date: Available online 20 May 2019Source: Neuroscience LettersAuthor(s): Shuaiyu Chen, Todd Jackson, Debo Dong, Xuemeng Zhang, Hong ChenAbstractAccording to the hedonic-inhibitory model, overeating occurs when active inhibitory capacities mediated by the prefrontal areas are overridden by hedonic-eating motivation mediated by the mesolimbic reward system. The inferior frontal gyrus (IFG) has a crucial role in inhibiting hedonic-cues response yet transcranial direct current stimulation (tDCS) studies have emphasized the dorsolateral prefrontal cortex (DLPFC), to the neglect of other executive network regions inc...
Background: Glucocorticoid replacement is commonly required to treat secondary adrenal insufficiency after surgical resection of unilateral cortisol-secreting adrenocortical adenomas. Here, we describe a patient with unilateral cortisol-secreting adenomas in which the preoperative use of mifepristone therapy was associated with recovery of the hypothalamic–pituitary–adrenal (HPA) axis, eliminating the need for postoperative glucocorticoid replacement. Case Presentation: A 66-year-old Caucasian man with type 2 diabetes mellitus, hyperlipidemia, hypertension, and obesity was hospitalized for Fournier’s gan...